Progression of antiretroviral therapy resistance early warning indicator in Burkina Faso between 2014 and 2017.
Keywords:
early warning indicators, resistance to ART, Burkina FasoAbstract
The widespread use of antiretrovirals (ARVs) to people living with HIV (PLHIV) is accompanied by the development of HIV resistance (R-ARV). We determined the performance of three early warning indicators (EWIs) associated with a high risk of R-ARV emergence in Burkina Faso through a repeated cross-sectional study between 2014 and 2017. We analyzed the evolution of the DPIs of R-ARV emergence over this period. These were DPI1 (Timely withdrawal of ARVs), DPI2 (Retention on ARV treatment "TARV" at 12 months) and DPI4 (ARV prescription practices). A total of 27 sites were evaluated. The median number of patients who withdrew ART on time changed from 61% in 2015, 60% in 2016 and 58% in 2017, respectively. No site reached the threshold of at least 95% in the 2014 and 2015 cohorts. The medians of retention on ART at 12 months for the 2014, 2015 and 2016 cohorts were 70%, 69% and 65% respectively. The 12-month ART retention threshold of at least 85% was only reached at two sites. Although ARV prescribing is in line with national guidelines, the quality of care offered to PLHIV regressed from 2014 to 2017 with a high risk of R-ARV emergence. To minimize this risk, therapeutic patient education and the system for tracking lost patients need to be strengthened.
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