Analyse coût-efficacité de la chimioprophylaxie du paludisme saisonnier chez les enfants de moins de 5 ans dans le département des Collines au Bénin en 2025

Rilwane DJIBRIL; Chales Patrick MAKOUTODE; SALAMI Lamidhi; MAKIN Mauricette

doi:10.4314/rasp.v8i1.16

Authors

Rilwane DJIBRIL IRSP-CAQ
Chales Patrick MAKOUTODE Institut Régional de Santé Publique IRSP
SALAMI Lamidhi Institut Régional de Santé Publique IRSP
MAKIN Mauricette

DOI:

https://doi.org/10.4314/rasp.v8i1.16

Keywords:

Seasonal malaria chemoprevention, cost-effectiveness analysis, children under 5 years, Benin, Monte Carlo

Abstract

Malaria remains a major public health challenge in sub-Saharan Africa, accounting for 40% of consultations and the leading cause of mortality among children under 5 years in Benin. This study aimed to analyze the cost-effectiveness of Seasonal Malaria Chemoprevention (SMC) among children under 5 years in the Collines department of Benin in 2025. This was a cost-effectiveness analysis conducted from March to April 2025, including 454 households selected through multi-stage probability sampling. Data were analyzed using Stata 18.4 and Python 3.10. Univariate and multivariate sensitivity analyses were performed with Monte Carlo simulations over 10,000 iterations. SMC achieved a 19.94% reduction in malaria cases and 32.50% reduction in deaths between 2023 and 2024. The total cost was 246,505,194.5 FCFA. The cost per DALY averted was 123,376 FCFA, 6.5 times below the WHO "very cost-effective" threshold. The probability of cost-effectiveness was 100% across all 10,000 simulations. SMC is a highly cost-effective intervention. Transitioning to a DOT3 strategy is recommended to maximize health and economic impact.

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